Australian Stosur, who has a history of suffering attacks of nerves in front of home fans, struggled to serve out the match at Rod Laver Arena and double-faulted on match point.
Veteran Leander Paes and his partner Samantha Stosur suffered a second round defeat in the mixed doubles event, ending India's campaign at the Australian Open.
Fifteenth seeds Samantha Stosur and Nenad Zimonjic claimed the mixed doubles title with a 6-4, 6-2 win against 14th seeds Chan Hao-Ching of Taiwan and Max Mirnyi of Belarus at Wimbledon on Sunday in the final match of the 2014 championships.
Serena Williams produced a serving masterclass to end local interest in the women's draw with a 6-4, 6-2 demolition of Samantha Stosur in the fourth round of the Australian Open on Monday.
French Open champion and home favourite Francesca Schiavone lost in the quarter-finals of the Italian Open on Friday as Samantha Stosur gained revenge for defeat in last year's Roland Garros final.
Russian fourth seed Elena Dementieva was shown the exit at the French Open with a 6-3, 4-6, 6-1 defeat by Australian Samantha Stosur in the third round in Paris on Saturday. The Olympic champion, who benefited from Jelena Dokic's retirement in the previous round while she was one set down, bowed out after two hours 12 minutes.
Stosur won the 2011 US Open, and has been as high as No. 4 in singles. In doubles, Stosur has been ranked No. 1 and won three Grand Slam trophies, most recently at the 2019 Australian Open.
The pair beat 14th seeds Elena Dementieva of Russia and Italian Flavia Pennetta in the final at the US Open.
Australian Samantha Stosur pulled off a stunning 6-2, 6-7, 8-6 victory over top seed Serena Williams on Wednesday to reach the semi-finals of the French Open for the second year in succession.
Australian Samantha Stosur booked her place in the French Open semi-finals with a 6-1, 6-3 victory over Romanian high school student Sorana Cirstea on Wednesday.
Last year's runner-up Samantha Stosur was knocked out in the French Open third round after a 6-4, 1-6, 6-3 defeat by Argentina's Gisela Dulko on Friday.
Gusty winds and half-empty stands gave no sense of the usual Parisian glamour as last year's French Open runner-up Samantha Stosur began with an easy win on Sunday and Lleyton Hewitt pulled out injured.
The father of Australia's Samantha Stosur was unable to contain his delight after his daughter upset Serena Williams in an ill-tempered U.S. Open final to win her maiden major singles title on Sunday.
Stosur recently announced this month that her partner Liz Astling gave birth to daughter Evie in June.
An inspired Francesca Schiavone became the first Italian woman to win a Grand Slam singles title on Saturday when she beat Australia's Samantha Stosur in the final of the French Open.
Denmark's Caroline Wozniacki claimed her 20th career title by beating top seed Samantha Stosur 6-2, 4-6, 7-5 in a thrilling Kremlin Cup tennis final on Sunday.
Maria Sharapova marched into the semi-finals of the Cincinnati Open after crushing Australian Samantha Stosur 6-3, 6-2 on Friday to set up a last four meeting with fellow-Russian Vera Zvonareva.
World number six Samantha Stosur has opted out of Australia's Fed Cup World Group playoff against Ukraine to concentrate on preparing for the clay-court season.
Samantha Stosur's win over world number one Caroline Wozniacki was not the only surprise for an unsuspecting crowd at the WTA Championships, where music, dance and even a frightened feline vied with the tennis for attention.
Italy's Flavia Pennetta outran and outsmarted Australian Samantha Stosur to win the LA Championships with a 6-4, 6-3 victory in Sunday's final.
US Open champion Samantha Stosur lost in the second round of the China Open on Tuesday, beaten for the second time in a week by Russian Maria Kirilenko.
Top seed Samantha Stosur reached her first final in eight months with a comeback 2-6, 6-3, 6-2 win over fourth-seeded Serbian Ana Ivanovic in the Kremlin Cup semi-finals on Saturday.
Top seed Samantha Stosur survived a scare against Alize Cornet before beating the Frenchwoman 7-6, 7-5 to reach the Kremlin Cup quarter-finals on Thursday.
World No 1 Serena Williams won a tense battle of U.S. Open champions by beating Australia's Samantha Stosur 7-6(7), 7-6(7) on Wednesday to reach the third round of the Western and Southern Open in Cincinnati.
The star pull-outs from this year's Commonwealth Games continue with French Open finalist Samantha Stosur becoming the latest to decide against competing in the Delhi event to focus on top WTA tournaments. The Australian tennis ace joins the country's top male tennis player Lleyton Hewitt in pulling out of the Games, according to an Australian Associated Press report.
Australia's Samantha Stosur employed a huge serve, hard forehand and deft backhand slice to upset Wimbledon champion Serena Williams 6-2, 3-6, 6-2 in the quarter-finals of the Stanford Classic on Friday.
Samantha Stosur underlined her credentials for next month's French Open by crushing Russia's Vera Zvonareva 6-0, 6-3 in Sunday's final of the Family Circle Cup to claim her second WTA Tour title.
Maria Sharapova edged out Samantha Stosur 6-3, 3-6, 6-1 to reach the quarter-finals of the DFS Classic grass court tournament
Australia's Sam Stosur has split with her long-time coach David Taylor, the former U.S. Open champion said on Saturday.
Images from Day 1 of the French Open 2012 tennis tournament at Roland Garros in Paris, on Sunday.
The unseeded Australians beat Zimbabwean Kevin Ullyett and Liezel Huber of South Africa to win the mixed doubles title.
Justine Henin won her first title since her comeback when she beat Australia's Samantha Stosur in the final at the Stuttgart indoor tournament on Sunday.
Maria Sharapova continued her untroubled progress at the Qatar Open on Friday, brushing aside Australia's Samantha Stosur 6-2, 6-4 to reach the semi-finals.
Grand Slam winners Samantha Stosur and Petra Kvitova strolled into the second round of the Dubai championships with straight sets wins on Tuesday after Australian Open champion Victoria Azarenka withdrew due to a foot injury.
Fifth-seeded Australian Samantha Stosur saved four match points in a thrilling third set and came back to beat Russian Elena Dementieva 6-3, 2-6, 7-6 to reach the quarter-finals of the U.S. Open on Sunday.
Samantha Stosur hopes to banish her home court demons on the way to more Grand Slam glory after failing to add to her major trophies in 2012, the Australian said on Friday.
Samantha Stosur became the highest seeded casualty so far at this year's Wimbledon when she suffered a 6-2, 0-6, 6-4 second round defeat by Dutch player Arantxa Rus to end Australia's interest in the singles.
Russian seventh seed Svetlana Kuznetsova struggled past Australian 30th seed Samantha Stosur 6-4, 6-7, 6-3 to book her place in the French Open final on Thursday. Kuznetsova will take on compatriot Dinara Safina, the world number one, in an all Russian final on Saturday.
Former world number one Maria Sharapova warmed up in style for the French Open by cruising to her first title in a year with a 6-2, 6-4 win over an an out-of-sorts Samantha Stosur at the Italian Open on Sunday.
Czech Petra Kvitova defeated titleholder Agnieszka Radwanska 6-2, 6-4 in the Dubai Championships on Thursday to set up a semi-final against Caroline Wozniacki.